Discriminatory suppression of homologous recombination by p53
نویسندگان
چکیده
منابع مشابه
Discriminatory suppression of homologous recombination by p53.
Homologous recombination (HR) is used in vertebrate somatic cells for essential, RAD51-dependent, repair of DNA double-strand-breaks (DSBs), but inappropriate HR can cause genome instability. A transcriptional transactivation-independent role for p53 in suppressing HR has been established, but is not detected in all HR assays. To address the basis of such exceptions, and the possibility that su...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2004
ISSN: 1362-4962,0305-1048
DOI: 10.1093/nar/gkh986